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神经肽Y与酒精中毒:遗传学、分子学及药理学证据

Neuropeptide y and alcoholism: genetic, molecular, and pharmacological evidence.

作者信息

Pandey Subhash C, Carr Lucinda G, Heilig Markus, Ilveskoski Erkki, Thiele Todd E

机构信息

Department of Psychiatry, Psychiatric Institute, University of Illinois, IL 60612, USA.

出版信息

Alcohol Clin Exp Res. 2003 Feb;27(2):149-54. doi: 10.1097/01.ALC.0000052706.21367.0E.

Abstract

This article presents the proceedings of a symposium presented at the combined meeting of the Research Society on Alcoholism and the International Society for Biomedical Research on Alcoholism, held in San Francisco, CA, in June 2002. The organizers and chairpersons were Subhash C. Pandey and Todd E. Thiele. The presentations were (1) Altered ethanol-induced sedation and ethanol drinking in mutant mice lacking specific NPY receptor, by Todd E. Thiele; (2) NPY in P and NP rats: polymorphism and mRNA expression, by Lucinda G. Carr; (3) The cAMP-dependent PKA in the central amygdala regulates alcohol intake through NPY gene, by Subhash C. Pandey; (4) Involvement of NPY in alcohol dependence: from animal models to human genetics, by Markus Heilig; and (5) Association of neuropeptide Y polymorphism with the occurrence of type 1 and type 2 alcoholism, by Erkki Ilveskoski.

摘要

本文介绍了2002年6月在加利福尼亚州旧金山举行的酒精中毒研究学会和酒精中毒国际生物医学研究学会联合会议上举办的一次研讨会的会议记录。组织者和主席是苏巴什·C·潘迪和托德·E·蒂勒。会议发言包括:(1)托德·E·蒂勒所做的“缺乏特定神经肽Y受体的突变小鼠中乙醇诱导的镇静作用和乙醇摄入的改变”;(2)露辛达·G·卡尔所做的“P和NP大鼠中的神经肽Y:多态性和mRNA表达”;(3)苏巴什·C·潘迪所做的“中央杏仁核中依赖cAMP的蛋白激酶A通过神经肽Y基因调节酒精摄入”;(4)马库斯·黑利格所做的“神经肽Y在酒精依赖中的作用:从动物模型到人类遗传学”;以及(5)埃尔基·伊尔韦斯科斯基所做的“神经肽Y多态性与1型和2型酒精中毒发生的关联”。

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