Gutiérrez M Purificación, Orduña Antonio, Dueñas Ana, Bratos Miguel Angel, Almaraz Ana, Alamo Rufino, Rodríguez Recio M Jesús, Rodríguez Marcos Henar, Rodríguez Torres Antonio
Area de Microbiología. Facultad de Medicina. Universidad de Valladolid. Spain.
Med Clin (Barc). 2003 Feb 1;120(3):97-8.
The aim of this paper was determine the prevalence of antibodies against Francisella tularensis in the representative sample of people from Castilla-León (Spain) before epidemic outbreak of end 1997.
We obtain 4,825 sera (between april-1996 and april-1997) of people from Castilla-León. All sera were tested by a microagglutination technique to detect antibodies against Francisella tularensis. The positive sera were tested to determine cross-reaction with Brucella, Yersinia enterocolitica and Proteus in the tube agglutination tests.
We detected antibodies against Francisella tularensis in 9 (0,19%) of the 4,825 sera. Only one serum from the 9 seropositive was positive in the tube agglutination against Brucella. None of the 9 sera were positive against the remaining bacterial antigen tested.
In the people of Castilla-León before 1997 the prevalence of antibodies against Francisella tularensis was 0,19%.
本文旨在确定1997年末疫情爆发前，西班牙卡斯蒂利亚-莱昂地区有代表性人群中抗土拉弗朗西斯菌抗体的流行情况。
我们获取了1996年4月至1997年4月期间卡斯蒂利亚-莱昂地区人群的4825份血清。所有血清均采用微量凝集技术检测抗土拉弗朗西斯菌抗体。对阳性血清进行试管凝集试验，以确定其与布鲁氏菌、小肠结肠炎耶尔森菌和变形杆菌的交叉反应。
在4825份血清中，我们检测到9份（0.19%）含有抗土拉弗朗西斯菌抗体。9份血清学阳性样本中只有1份在针对布鲁氏菌的试管凝集试验中呈阳性。9份血清中没有一份对其余检测的细菌抗原呈阳性。
1997年以前，卡斯蒂利亚-莱昂地区人群中抗土拉弗朗西斯菌抗体的流行率为0.19%。
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