格列波脲治疗糖尿病的临床试验。
Clinical trial of glibornuride in diabetes.
作者信息
Logie A W, Stowers J M
出版信息
Br Med J. 1975 Aug 30;3(5982):514-5. doi: 10.1136/bmj.3.5982.514.
Abstract
Glibornuride is an addition to the second-generation sulphonylureas, that has been shown in clinical trials to be effective and non-toxic. Twenty-three diabetics who were poorly controlled on other oral hypoglycaemic agents and seven newly diagnosed diabetics were treated with glibornuride. The efficacy and lack of toxicity of this drug was confirmed, but there was no evidence to suggest that it is significantly more potent than other sulphonylureas. It does not seem to represent a significant therapeutic advance.
摘要
格列波脲是第二代磺酰脲类药物中的一种，临床试验表明其有效且无毒。23名使用其他口服降糖药控制不佳的糖尿病患者和7名新诊断的糖尿病患者接受了格列波脲治疗。该药物的有效性和无毒性得到了证实，但没有证据表明它比其他磺酰脲类药物更有效。它似乎并没有带来显著的治疗进展。
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Br Med J. 1969 May 10;2(5653):353-5. doi: 10.1136/bmj.2.5653.353.
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[Therapy of diabetes in adults using Glibornurid. Results and clinical studies].[使用格列本脲治疗成人糖尿病。结果与临床研究]
Dtsch Med Wochenschr. 1973 May 4;98(18):915-9. doi: 10.1055/s-0028-1106931.
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