Bhattacharya K F, Nouri S, Olanow C W, Yahr M D, Kaufmann H
Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA.
Parkinsonism Relat Disord. 2003 Mar;9(4):221-4. doi: 10.1016/s1353-8020(02)00053-6.
Less than a consensus exists as to whether chronic treatment with selegiline in combination with levodopa/carbidopa in patients with Parkinson's disease, is associated with more pronounced orthostatic hypotension than treatment with levodopa/carbidopa alone. To resolve this issue, we compared orthostatic tolerance and autonomic reflexes in 95 patients with Parkinson's disease treated chronically with either selegiline alone (n = 10), levodopa/carbidopa alone (n = 49) or both agents combined (n = 36). Supine heart rate and blood pressure, autonomic cardiovascular reflexes and the frequency and magnitude of orthostatic hypotension were similar in all three treatment groups.
对于帕金森病患者，司来吉兰与左旋多巴/卡比多巴联合长期治疗是否比单独使用左旋多巴/卡比多巴更易导致明显的体位性低血压，目前尚无共识。为解决这一问题，我们比较了95例长期接受治疗的帕金森病患者的体位耐受性和自主反射，这些患者分别单独接受司来吉兰治疗（n = 10）、单独接受左旋多巴/卡比多巴治疗（n = 49）或两种药物联合治疗（n = 36）。所有三个治疗组的仰卧心率、血压、自主心血管反射以及体位性低血压的频率和严重程度均相似。
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