Omenn G S
West J Med. 1976 Dec;125(6):434-51.
The distribution and functions of certain neurotransmitter substances seem to correlate with clinical, anatomical and physiological evidence about the mediation of normal and abnormal behaviors in man, though much remains to be learned. The biosynthetic and metabolic pathways, receptors and reuptake mechanisms, and relationships to cyclic nucleotides for several major neurotransmitters are characterized, as well as the specific actions of many behavior-modifying drugs employed clinically. Experimental systems, including nerve cells in culture, permit tests of molecular actions inferred from biochemical and neurophysiological analyses in intact brain. This selective review emphasizes advances in neurochemistry which provide a context for current and future research on neurological and psychiatric disorders encountered in clinical practice.
某些神经递质物质的分布和功能似乎与关于人类正常和异常行为调节的临床、解剖学及生理学证据相关，尽管仍有许多有待了解。文中描述了几种主要神经递质的生物合成和代谢途径、受体及再摄取机制，以及它们与环核苷酸的关系，还介绍了临床上使用的许多行为调节药物的具体作用。包括培养神经细胞在内的实验系统，能够对从完整大脑的生化和神经生理学分析推断出的分子作用进行测试。这篇选择性综述着重介绍了神经化学领域的进展，这些进展为临床实践中遇到的神经和精神疾病的当前及未来研究提供了背景。
