TEL-AML1融合基因在土耳其儿童急性淋巴细胞白血病中的预后意义
Prognostic significance of the TEL-AML1 fusion gene in pediatric acute lymphoblastic leukemia in Turkey.
作者信息
Ozbek Ugur, Sirma Sema, Agaoglu Leyla, Yuksel Lebriz, Anak Sema, Yildiz Inci, Devecioglu Omer, Timur Cetin, Meral Adalet, Gedikoglu Gunduz
机构信息
Department of Genetics, Institute for experimental Medial Research, Istanbul University, Istanbul.
出版信息
J Pediatr Hematol Oncol. 2003 Mar;25(3):204-8. doi: 10.1097/00043426-200303000-00005.
PURPOSE
The t(12;21) translocation is the most common reciprocal chromosomal rearrangement in pediatric acute lymphoblastic leukemia (ALL). This translocation fuses two genes, TEL and AML1, and results in the production of the TEL-AML1 fusion protein. The authors investigated the incidence and prognostic significance of the TEL-AML1 fusion gene in patients with ALL in Turkey.
METHODS
The authors analyzed 219 children with ALL using the reverse transcription-polymerase chain reaction.
RESULTS
The TEL-AML1 fusion transcript was detected in 20.1% (44/219) of newly diagnosed children with ALL. -positive patients had precursor B-cell ALL and were 3 to 10 years old at diagnosis. -positive patients had a significantly lower rate of relapse compared with -negative patients. -positive patients have a higher overall survival rate than -negative patients.
CONCLUSIONS
These data support that the presence of at diagnosis is an independent favorable prognostic indicator in patients with ALL in Turkey.
目的
t(12;21)易位是儿童急性淋巴细胞白血病（ALL）中最常见的相互染色体重排。这种易位融合了两个基因，TEL和AML1，并导致TEL-AML1融合蛋白的产生。作者调查了土耳其ALL患者中TEL-AML1融合基因的发生率及其预后意义。
方法
作者使用逆转录-聚合酶链反应分析了219例ALL患儿。
结果
在20.1%（44/219）新诊断的ALL患儿中检测到TEL-AML1融合转录本。阳性患者为前体B细胞ALL，诊断时年龄为3至10岁。与阴性患者相比，阳性患者的复发率显著较低。阳性患者的总生存率高于阴性患者。
结论
这些数据支持在土耳其ALL患者中，诊断时的存在是一个独立的有利预后指标。
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