Müller U, Wirth W, Kramer H, Hauss G M, Hauss W H
Int J Clin Pharmacol Biopharm. 1975 Jul;12(1-2):192-8.
Wet weight of cotton-pellet granuloma and 35SO4-uptake in the acid mucopolysaccharides (AMPS) of granulation tissue of rats and the number of plaque forming cells (PFC) of mice were investigated after the treatment with antilymphocyte globulin, prednisolone, cyclophosphamide and azathioprine. In this way, the effect of these substances could be observed in a mesenchymal reaction and in an immune reaction. The substances are mesenchymosuppressive as well as immunosuppressive, but the present results show that the effective dosage is higher for mesenchymal suppression than for immunosuppression. Antilymphocyte globulin did not cause an alteration of the 35SO4-uptake in AMPS. These experimental findings confirm the clinical experience in the treatment of the so-called autoimmunological diseases which are primary localized in connective tissue. These diseases need a higher dosage of cytostatic substances, glucocorticoids and antilymphocyte globulin in times of acute inflammatory exacerbation than in the chronic phase.
在用抗淋巴细胞球蛋白、泼尼松龙、环磷酰胺和硫唑嘌呤治疗后，对大鼠棉球肉芽肿湿重、肉芽组织酸性粘多糖（AMPS）中35SO4摄取量以及小鼠空斑形成细胞（PFC）数量进行了研究。通过这种方式，可以在间充质反应和免疫反应中观察这些物质的作用。这些物质具有间充质抑制作用和免疫抑制作用，但目前的结果表明，间充质抑制的有效剂量高于免疫抑制的有效剂量。抗淋巴细胞球蛋白未引起AMPS中35SO4摄取量的改变。这些实验结果证实了在治疗主要局限于结缔组织的所谓自身免疫性疾病方面的临床经验。与慢性期相比，这些疾病在急性炎症加重期需要更高剂量的细胞抑制物质、糖皮质激素和抗淋巴细胞球蛋白。
