Rubinstein P, Suciu-Foca N, Nicholson J F, Fotino M, Molinaro A, Harisiadis L, Hardy M A, Reemtsma K, Allen F H
J Exp Med. 1976 May 1;143(5):1277-82. doi: 10.1084/jem.143.5.1277.
The HLA and Bf genotypes were determined in 10 families with one or more children with JDM. A statistically significant association was found between HLA-D-identity and the chance to present JDM within a sibship. No such association was detectable with the SD antigens. A highly significant increase in the frequency of intra-HLA recombination was also found in these families.
对10个有一个或多个患幼年皮肌炎(JDM)孩子的家庭进行了HLA和Bf基因型测定。发现HLA - D一致性与同胞中出现JDM的几率之间存在统计学显著关联。而对于SD抗原,未检测到此类关联。在这些家庭中还发现HLA内部重组频率显著增加。