Yoshimi Itsuro, Ohshima Akira, Ajiki Wakiko, Tsukuma Hideaki, Sobue Tomotaka
Cancer Information and Epidemiology Division, National Cancer Center Research Institute, Tokyo, Japan.
Jpn J Clin Oncol. 2003 Feb;33(2):98-104. doi: 10.1093/jjco/hyg019.
Trends in the incidence rate of lung cancer by histological type were examined, based on data from the Osaka Cancer Registry (OCR), Japan and the Surveillance, Epidemiology and End Results Program (SEER), USA. Among males, an increasing trend was observed for adenocarcinoma in both registries. In the OCR, the incidence rate of adenocarcinoma has recently overtaken that of squamous cell carcinoma, whereas in the SEER, adenocarcinoma had already taken the lead since 1990-93. For squamous cell carcinoma, the decreasing trends in the OCR were consistent with a previous study, whereas in the SEER, the decline was earlier and steeper. For small cell carcinoma, the incidence rate was leveling off in the OCR, whereas it was already in decline in the SEER. For large cell carcinoma, the decreasing trend began earlier in the SEER. Among females in both registries, the incidence rate of adenocaricinoma has clearly been on the increase, whereas in other histological types the incidence rates were decreasing or at least leveling off. As for the age-specific incidence rate, different patterns were observed between the two registries: in the OCR, the incidence rate was on the increase in older age groups such as 70-74 years and also in younger age groups such as 45-49 years, whereas it decreased in intermediate age groups such as 55-59. In contrast, stable decreasing trends were observed in the SEER, except for adenocarcinoma. The increase in incidence rate observed among younger age groups in the OCR should be carefully monitored.
基于日本大阪癌症登记处（OCR）和美国监测、流行病学与最终结果计划（SEER）的数据，对肺癌组织学类型的发病率趋势进行了研究。在男性中，两个登记处的腺癌发病率均呈上升趋势。在OCR中，腺癌的发病率最近已超过鳞状细胞癌，而在SEER中，腺癌自1990 - 1993年以来就已领先。对于鳞状细胞癌，OCR中的下降趋势与先前的研究一致，而在SEER中，下降更早且更陡峭。对于小细胞癌，OCR中的发病率趋于平稳，而在SEER中已经在下降。对于大细胞癌，SEER中的下降趋势开始得更早。在两个登记处的女性中，腺癌的发病率明显呈上升趋势，而其他组织学类型的发病率则在下降或至少趋于平稳。至于年龄特异性发病率，两个登记处观察到不同的模式：在OCR中，70 - 74岁等老年组以及45 - 49岁等年轻组的发病率呈上升趋势，而在55 - 59岁等中年组中则下降。相比之下，除腺癌外，SEER中观察到稳定的下降趋势。OCR中年轻年龄组发病率的上升应予以密切监测。
