Arteaga Carlos L
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Breast Cancer Res. 2003;5(2):96-100. doi: 10.1186/bcr574. Epub 2003 Feb 3.
Overexpression of the HER2/Neu (ErbB2) proto-oncogene is associated with breast cancer progression and poor patient prognosis. Herceptin (trastuzumab) is a humanized IgG1 against the ectodomain of the HER2 receptor. In combination with chemotherapy, it induces regression of HER2-overexpressing metastatic breast tumors and prolongs patient survival. Single-agent Herceptin in patients with HER2-amplified breast tumors also induces a definite objective response and clinical benefit rates, and is well tolerated. These data suggest that Herceptin is an effective first-line single-agent therapy for a predictable cohort of metastatic breast cancers and can therefore be used as a platform for therapeutic discovery against tumors that overexpress HER2.
HER2/Neu(ErbB2)原癌基因的过表达与乳腺癌进展及患者预后不良相关。赫赛汀(曲妥珠单抗)是一种针对HER2受体胞外域的人源化IgG1。与化疗联合使用时,它可诱导HER2过表达的转移性乳腺肿瘤消退并延长患者生存期。对于HER2扩增的乳腺肿瘤患者,单药使用赫赛汀也可诱导明确的客观缓解率和临床获益率,且耐受性良好。这些数据表明,赫赛汀是一种针对可预测的转移性乳腺癌群体的有效的一线单药疗法,因此可作为针对过表达HER2的肿瘤进行治疗探索的平台。