Vlastos George A, Tangney Christine C, Rosenson Robert S
Lipoprotein and Hemorheology Research Facility, Department of Medicine and Pathology, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL, USA.
Clin Hemorheol Microcirc. 2003;28(1):41-9.
This study investigated the impact of oral fluid intake on blood rheology of 17 healthy adults following a 12-14 hour overnight fast from food and drink. An oral fluid load of 500 ml was consumed every 30 minutes for 2 hours. Blood viscosity values at shear rates of 1, 10 and 100 s(-1) were reduced (p<0.05 to p<0.01) at 30 and 120 minutes following hydration; however, these differences were not significant after hematocrit correction. With fluid intake, both uncorrected and corrected viscous component of blood viscoelasticity at oscillatory shear rate of 1 s(-1) and at a constant frequency of 2 Hz were reduced (p<0.05 to p<0.001) at all time points as compared to fasting values. The corrected elastic component of blood viscoelasticity increased 90 minutes after hydration (p<0.05). An overnight fast is accompanied by rheological abnormalities that are altered by fluid intake.
本研究调查了17名健康成年人在禁食禁水12 - 14小时的过夜禁食后，口服液体摄入对血液流变学的影响。在2小时内，每30分钟摄入500毫升口服液体负荷。水化后30分钟和120分钟时，剪切速率为1、10和100 s(-1)时的血液粘度值降低（p<0.05至p<0.01）；然而，在血细胞比容校正后，这些差异并不显著。随着液体摄入，与禁食值相比，在振荡剪切速率为1 s(-1)且频率为2 Hz恒定的情况下，血液粘弹性的未校正和校正粘性成分在所有时间点均降低（p<0.05至p<0.001）。水化90分钟后，血液粘弹性的校正弹性成分增加（p<0.05）。过夜禁食伴随着流变学异常，而这种异常会因液体摄入而改变。
