Pérez-Schael Irene, Escalona Marisol, Salinas Belén, Materán Mercedes, Pérez María Egleé, González Germán
Instituto de Biomedicina-Fuvesin, Universidad Central de Venezuela, Ministerio de Salud y Desarrollo Social, Carcas, Venezuela.
Pediatr Infect Dis J. 2003 Mar;22(3):234-9. doi: 10.1097/01.inf.0000055064.76457.f3.
The first licensed rotavirus vaccine was withdrawn from use in the United States because of a low risk of intussusception. Consequently tests of new rotavirus vaccines will require some baseline knowledge of the rates and treatment of intussusception in countries where these vaccines will be tested. Therefore the objective of this study was to assess hospitalization rates and describe the epidemiologic and clinical characteristics of intussusception in Carabobo, Venezuela.
This study reviewed hospital data and clinical records of pediatric patients with intussusception admitted to eight hospitals in Carabobo between January 1, 1998 and December 31, 2001.
For the 4-year period the average annual hospitalization rate for intussusception among infants (<1 year old) in Carabobo was 35 per 100 000 infants per year (range, 22 to 44), and intussusception was more common among boys (58 per 100 000 infants per year) than girls (29 per 100 000 infants per year) (P = 0.006). One of 67 cases occurred in the first 3 months of life (0 to 2), 55% (37) patients were 3 to 5 months old, 31% (21) were 6 to 11 months old and 12% (8) were > or =12 months old. Surgical reduction was required in 88% (52 of 59) of infants but only 1 required bowel resection. The monthly distribution of intussusception-associated hospitalizations showed no consistent seasonal pattern with the seasonality observed for patients hospitalized with rotavirus disease.
This study provides some data about the incidence of intussusception and its epidemiology in a developing country where current or future field trials with rotavirus vaccine will be conducted.
首款获得许可的轮状病毒疫苗因肠套叠风险较低而在美国停止使用。因此，新轮状病毒疫苗的测试需要了解这些疫苗将在哪些国家进行测试的肠套叠发病率和治疗的一些基线知识。因此，本研究的目的是评估委内瑞拉卡拉沃沃州的住院率，并描述肠套叠的流行病学和临床特征。
本研究回顾了1998年1月1日至2001年12月31日期间卡拉沃沃州八家医院收治的肠套叠儿科患者的医院数据和临床记录。
在这4年期间，卡拉沃沃州婴儿（<1岁）肠套叠的年平均住院率为每10万名婴儿每年35例（范围为22至44例），肠套叠在男孩中（每10万名婴儿每年58例）比女孩中（每10万名婴儿每年29例）更常见（P = 0.006）。67例病例中有1例发生在生命的前3个月（0至2岁），55%（37例）患者为3至5个月大，31%（21例）为6至11个月大，12%（8例）为≥12个月大。88%（59例中的52例）的婴儿需要手术复位，但只有1例需要肠切除。与肠套叠相关的住院月度分布与轮状病毒疾病住院患者观察到的季节性没有一致的季节性模式。
本研究提供了一些关于在一个将进行当前或未来轮状病毒疫苗现场试验的发展中国家肠套叠发病率及其流行病学的数据。
