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关于维持生命治疗的偏好稳定性:对养老院居民的一项为期两年的前瞻性研究。

Stability of preferences regarding life-sustaining treatment: a two-year prospective study of nursing home residents.

作者信息

McParland Elaine, Likourezos Antonios, Chichin Eileen, Castor Tita, Paris BE Barbara E

机构信息

Mount Sinai School of Medicine, New York, NY, USA.

出版信息

Mt Sinai J Med. 2003 Mar;70(2):85-92.

Abstract

BACKGROUND

The use of advance directives is based on the consensus that physicians should respect preferences expressed by competent patients about future treatments. Patient preferences are, however, subject to change and may be influenced by a number of factors. The purpose of our study was to evaluate the durability over time of decisions made regarding terminal care of mentally intact nursing home patients and the influence of such factors as intervening illness, loss of significant others, and cognitive, emotional and functional decline.

METHODS

We undertook a longitudinal prospective cohort study in which 65 mentally competent nursing home patients were interviewed at three intervals (at baseline and after one and two years). For each patient, demographic, medical and socioeconomic data were collected and assessment of mood, function, cognition and preference for life-sustaining therapies (including cardiopulmonary resuscitation and parenteral and enteral nutrition) was obtained.

RESULTS

Preferences regarding cardiopulmonary resuscitation and parenteral and enteral nutrition changed over both the 12- and 24-month study periods. Only degree of change in cognitive status proved to be predictive of changes in decision. Gender, presence or absence of depression, change in level of functional abilities and intercurrent illness or stressor did not influence change regarding life-sustaining therapy.

CONCLUSIONS

In light of our findings, we suggest that periodic re-evaluation of these advance directives be performed and that ongoing discussions be initiated with their patients by health care professionals.

摘要

背景

预先指示的使用基于这样一种共识,即医生应尊重有行为能力的患者对未来治疗所表达的偏好。然而,患者的偏好可能会发生变化,并可能受到多种因素的影响。我们研究的目的是评估精神健全的养老院患者临终关怀决策随时间的持续性,以及诸如疾病、重要他人的离世、认知、情感和功能衰退等因素的影响。

方法

我们进行了一项纵向前瞻性队列研究,对65名精神健全的养老院患者进行了三次访谈(基线时、1年后和2年后)。收集了每位患者的人口统计学、医学和社会经济数据,并对其情绪、功能、认知以及维持生命治疗的偏好(包括心肺复苏和肠外及肠内营养)进行了评估。

结果

在12个月和24个月的研究期间,关于心肺复苏和肠外及肠内营养的偏好都发生了变化。只有认知状态的变化程度被证明是决策变化的预测因素。性别、是否存在抑郁、功能能力水平的变化以及并发疾病或压力源均未影响维持生命治疗方面的变化。

结论

根据我们的研究结果,我们建议定期重新评估这些预先指示,并由医疗保健专业人员与患者展开持续讨论。

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