幽门螺杆菌感染：细胞毒素相关基因A（CagA）特异性抗体与临床结局相关，但与宿主的人类白细胞抗原（HLA）-Ⅱ类多态性无关。

Helicobacter pylori infection: CagA-specific antibodies are associated with clinical outcome, but not with HLA-class II polymorphisms of the host.

作者信息

Kunstmann Erdmute, Hardt Cornelia, Crabtree Jean E, Suerbaum Sebastian, Epplen Jörg T

机构信息

Department of Human Genetics, Ruhr-University, Bochum, Germany.

出版信息

Int J Med Microbiol. 2003 Feb;292(7-8):537-40. doi: 10.1078/1438-4221-00237.

DOI:10.1078/1438-4221-00237

PMID:12635936

Abstract

In order to investigate the interrelation between immunogenetic host and bacterial factors the T-cell receptor (TCR) polymorphism TCRBV6S1 A/B, HLA-DRB1 alleles and cagA status was analyzed in 380 unrelated German individuals. H. pylori infection with cagA-positive bacterial strains was significantly associated with peptic ulcer disease in the German cohort. Patients homozygous for the non-functional TCRBV6S1B allele and presenting with peptic ulcer disease showed no CagA-specific antibodies in the majority of cases. There was no association between HLA-DRB1 alleles and the CagA status of infected individuals, although certain alleles show significant association to the infection status in different populations.

摘要

为了研究免疫遗传宿主因素与细菌因素之间的相互关系，对380名无亲缘关系的德国个体的T细胞受体（TCR）多态性TCRBV6S1 A/B、HLA - DRB1等位基因和cagA状态进行了分析。在德国队列中，感染cagA阳性菌株的幽门螺杆菌与消化性溃疡病显著相关。携带无功能TCRBV6S1B等位基因纯合子且患有消化性溃疡病的患者，在大多数情况下未检测到CagA特异性抗体。HLA - DRB1等位基因与受感染个体的CagA状态之间没有关联，尽管某些等位基因在不同人群中与感染状态存在显著关联。