Effect of cyclooxygenase-2 inhibitors on blood pressure.

OBJECTIVE

To evaluate the effect of cyclooxygenase-2 selective inhibitors (CSIs) on blood pressure.

DATA SOURCES

Clinical literature accessed through MEDLINE (1966-May 2002). Key search terms included COX-2 selective inhibitors; anti-inflammatory agents, nonsteroidal; celecoxib; rofecoxib; and hypertension.

DATA SYNTHESIS

Data from prospective studies on the effects of CSIs on blood pressure are conflicting. Several studies have reported increased blood pressure as an adverse effect of CSIs.

CONCLUSIONS

Additional studies are needed to evaluate the effects of CSIs on blood pressure. CSIs should be used with caution in hypertensive patients and blood pressure monitored closely if a CSI is indicated.