糖尿病中血小板过度活化及血小板与内皮细胞相互关系的相关机制
Mechanisms involved in platelet hyperactivation and platelet-endothelium interrelationships in diabetes mellitus.
作者信息
Trovati Mariella, Anfossi Giovanni
机构信息
Diabetes Unit, Department of Clinical and Biological Sciences, University of Turin, San Luigi Gonzaga Hospital, Orbassano 10043, Turin, Italy.
出版信息
Curr Diab Rep. 2002 Aug;2(4):316-22. doi: 10.1007/s11892-002-0020-7.
PMID:12643191
Abstract
This article discusses the recent findings about the mechanisms involved in platelet hyperactivation in diabetes mellitus. Particular attention is focused on the advances pertaining to 1) new features of platelet activation; 2) the role of calcium fluxes; 3) the role of glucose, insulin, and insulin resistance; 4) the role of nitric oxide; and 5) the role of endothelium.
摘要
本文讨论了有关糖尿病中血小板过度活化所涉及机制的最新研究结果。特别关注以下方面的进展：1）血小板活化的新特征；2）钙通量的作用；3）葡萄糖、胰岛素和胰岛素抵抗的作用；4）一氧化氮的作用；5）内皮的作用。
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