Rodriguez Montserrat, Bonnet-Delpon Danièle, Bégué Jean Pierre, Robert Anne, Meunier Bernard
Laboratoire de Chimie de Coordination du CNRS, 205, route de Narbonne, 31077 Toulouse Cedex 4, France.
Bioorg Med Chem Lett. 2003 Mar 24;13(6):1059-62. doi: 10.1016/s0960-894x(03)00076-3.
The alkylating properties of two artemisinin derivatives bearing a trifluoromethyl substituent at C10 were evaluated toward manganese(II) tetraphenylporphyrin, considered as a heme model. Chlorin-type covalent adducts were obtained by alkylation of the porphyrin ring by C-centered radicals derived from reductive activation of the peroxide function of the drugs.
评估了两种在C10位带有三氟甲基取代基的青蒿素衍生物对被视为血红素模型的四苯基卟啉锰（II）的烷基化性质。通过药物过氧化物官能团的还原活化产生的C中心自由基对卟啉环进行烷基化反应，得到了二氢卟吩型共价加合物。
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