小鼠唾液中一种抗补体因子分泌的α-肾上腺素能调节

Alpha-adrenergic regulation of the secretion of an anticomplementary factor in mouse saliva.

作者信息

Wallace L J, Partlow L M, Ellis M E, Woodbury D M

出版信息

Proc Soc Exp Biol Med. 1976 May;152(1):99-104. doi: 10.3181/00379727-152-39337.

Abstract

Mouse saliva contains a potent inhibitor of complement activity. The secretion of this inhibitor appears to be regulated by action on alpha-adrenergic receptors for two reasons. First, an alpha-agonist (norepinephrine) elicited saliva with a 260-fold higher specific activity of the inhibitor than that obtained with a cholinergic agent (pilocarpine). Second, the alpha-agonist elicited saliva having 43-foldgreater specific activity than that obtained following administration of a beta-adrenergic agonist (isoproterenol). This anticomplementary factor probably proteolytically degrades one or more of the complement components since it is inhibited by several protease inhibitors. The salivary anticomplementary factor is more potent than trypsin, chymotrypsin, thrombin, or Kallikrein. The anticomplementary factor has a pattern of inhibition like that of Kallikrein but unlike those of trypsin or chymotrypsin.

摘要

小鼠唾液中含有一种强效补体活性抑制剂。这种抑制剂的分泌似乎受α-肾上腺素能受体作用的调节，原因有二。其一，α-激动剂（去甲肾上腺素）引发的唾液中抑制剂的比活性比胆碱能药物（毛果芸香碱）引发的唾液高260倍。其二，α-激动剂引发的唾液比给予β-肾上腺素能激动剂（异丙肾上腺素）后获得的唾液比活性高43倍。这种抗补体因子可能通过蛋白水解作用降解一种或多种补体成分，因为它受到几种蛋白酶抑制剂的抑制。唾液抗补体因子比胰蛋白酶、糜蛋白酶、凝血酶或激肽释放酶更有效。该抗补体因子的抑制模式与激肽释放酶相似，但与胰蛋白酶或糜蛋白酶不同。