上皮内复制缺陷的原养型沙门氏菌突变体的分子特征分析。
Molecular characterization of the prototrophic Salmonella mutants defective for intraepithelial replication.
作者信息
Suvarnapunya Akamol E, Zurawski Daniel V, Guy Rebecca L, Stein Murry A
机构信息
Department of Microbiology & Molecular Genetics, University of Vermont, 95 Carrigan Drive, Burlington, VT 05405, USA.
出版信息
Infect Immun. 2003 Apr;71(4):2247-52. doi: 10.1128/IAI.71.4.2247-2252.2003.
Abstract
Three MudJ prototrophs demonstrated that intracellular replication is a Salmonella virulence trait (K. Y. Leung and B. B. Finlay, Proc. Natl. Acad. Sci. USA, 88:11470-11474, 1991). mutS and mutH are disrupted in mutants 3-11 and 12-23, and ssaQ is disrupted in mutant 17-21. Further analysis revealed that loss of Salmonella pathogenicity island 2 function underlies the intracellular replication defect of 3-11 and 17-21.
摘要
三个MudJ原养型菌株表明细胞内复制是沙门氏菌的一种毒力特性（K.Y.梁和B.B.芬利，《美国国家科学院院刊》，88:11470 - 11474，1991）。在突变体3 - 11和12 - 23中mutS和mutH被破坏，在突变体17 - 21中ssaQ被破坏。进一步分析表明，沙门氏菌致病岛2功能的丧失是3 - 11和17 - 21细胞内复制缺陷的基础。
相似文献
1
Molecular characterization of the prototrophic Salmonella mutants defective for intraepithelial replication.
Infect Immun. 2003 Apr;71(4):2247-52. doi: 10.1128/IAI.71.4.2247-2252.2003.
2
Aggregation of host endosomes by Salmonella requires SPI2 translocation of SseFG and involves SpvR and the fms-aroE intragenic region.
Mol Microbiol. 2000 Sep;37(6):1417-35. doi: 10.1046/j.1365-2958.2000.02092.x.
3
Effect of mutS and recD mutations on Salmonella virulence.
Infect Immun. 1999 Nov;67(11):6168-72. doi: 10.1128/IAI.67.11.6168-6172.1999.
4
High mutation frequencies among Escherichia coli and Salmonella pathogens.
Science. 1996 Nov 15;274(5290):1208-11. doi: 10.1126/science.274.5290.1208.
5
In vitro and in vivo studies of MutS, MutL and MutH mutants: correlation of mismatch repair and DNA recombination.
DNA Repair (Amst). 2003 Apr 2;2(4):387-405. doi: 10.1016/s1568-7864(02)00245-8.
6
DNA mismatch correction in Haemophilus influenzae: characterization of MutL, MutH and their interaction.
DNA Repair (Amst). 2004 Dec 2;3(12):1561-77. doi: 10.1016/j.dnarep.2004.06.014.
7
Thermus thermophilus MutS2, a MutS paralogue, possesses an endonuclease activity promoted by MutL.
J Biochem. 2004 Mar;135(3):375-84. doi: 10.1093/jb/mvh045.
8
Functional transfer of Salmonella pathogenicity island 2 to Salmonella bongori and Escherichia coli.
Infect Immun. 2004 May;72(5):2879-88. doi: 10.1128/IAI.72.5.2879-2888.2004.
9
Dominant negative mutator mutations in the mutS gene of Escherichia coli.
J Bacteriol. 1994 Sep;176(17):5393-400. doi: 10.1128/jb.176.17.5393-5400.1994.
10
The mismatch repair system (mutS, mutL and uvrD genes) in Pseudomonas aeruginosa: molecular characterization of naturally occurring mutants.
Mol Microbiol. 2002 Mar;43(6):1641-50. doi: 10.1046/j.1365-2958.2002.02855.x.
引用本文的文献
1
Proteome of Salmonella Enterica Serotype Typhimurium Grown in a Low Mg/pH Medium.
J Proteomics Bioinform. 2009;2:388-397. doi: 10.4172/jpb.1000099.
本文引用的文献
1
The role of DNA base excision repair in the pathogenesis of Salmonella enterica serovar Typhimurium.
Mol Microbiol. 2003 Apr;48(2):549-59. doi: 10.1046/j.1365-2958.2003.03460.x.
2
SseA acts as the chaperone for the SseB component of the Salmonella Pathogenicity Island 2 translocon.
Mol Microbiol. 2003 Mar;47(5):1341-51. doi: 10.1046/j.1365-2958.2003.03373.x.
3
A hypermutator phenotype attenuates the virulence of Listeria monocytogenes in a mouse model.
Mol Microbiol. 2002 May;44(3):877-87. doi: 10.1046/j.1365-2958.2002.02929.x.
4
SseBCD proteins are secreted by the type III secretion system of Salmonella pathogenicity island 2 and function as a translocon.
J Bacteriol. 2001 Oct;183(20):6036-45. doi: 10.1128/JB.183.20.6036-6045.2001.
5
Length of the flagellar hook and the capacity of the type III export apparatus.
Science. 2001 Mar 23;291(5512):2411-3. doi: 10.1126/science.1058366. Epub 2001 Feb 22.
6
Spa33, a cell surface-associated subunit of the Mxi-Spa type III secretory pathway of Shigella flexneri, regulates Ipa protein traffic.
Infect Immun. 2001 Apr;69(4):2180-9. doi: 10.1128/IAI.69.4.2180-2189.2001.
7
SifA permits survival and replication of Salmonella typhimurium in murine macrophages.
Cell Microbiol. 2001 Feb;3(2):75-84. doi: 10.1046/j.1462-5822.2001.00087.x.
8
Aggregation of host endosomes by Salmonella requires SPI2 translocation of SseFG and involves SpvR and the fms-aroE intragenic region.
Mol Microbiol. 2000 Sep;37(6):1417-35. doi: 10.1046/j.1365-2958.2000.02092.x.
9
Salmonella maintains the integrity of its intracellular vacuole through the action of SifA.
EMBO J. 2000 Jul 3;19(13):3235-49. doi: 10.1093/emboj/19.13.3235.
10
Virulence and mutation rates of Salmonella typhimurium strains with increased mutagenic strength in a mouse model.
FEMS Microbiol Lett. 2000 Jun 15;187(2):145-50. doi: 10.1111/j.1574-6968.2000.tb09151.x.
Zotero 插件