Li Cong, Wong Wing-Tak
Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China.
J Org Chem. 2003 Apr 4;68(7):2956-9. doi: 10.1021/jo026436+.
A convenient synthetic route to 1,4-bis(tert-butoxycarbonylmethyl)tetraazacyclododecane (cyclen) (1) with high yield and excellent regioselectivity is described. Compound 1 reacted with a range of functionalized alkyl halides under two reaction conditions to give mono-N-alkylated 1,4-bis(tert-butoxycarbonylmethyl)tetraazacyclododecane (2-9) in good yield.
描述了一种便捷的合成路线，可高产率且具有优异区域选择性地制备1,4-双(叔丁氧羰基甲基)四氮杂环十二烷(环轮烯)(1)。化合物1在两种反应条件下与一系列功能化卤代烃反应，以良好的产率得到单-N-烷基化的1,4-双(叔丁氧羰基甲基)四氮杂环十二烷(2 - 9)。
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