急性髓性白血病细胞中Syndecan-1（CD138）的表达——一项免疫电子显微镜研究

Syndecan-1 (CD138) expression in acute myeloblastic leukemia cells--an immuno electron microscopic study.

作者信息

Seftalioglu Aysel, Karakus Sema, Dundar Semra, Can Belgin, Erdemli Esra, Irmak M Kemal, Oztas Emin, Korkmaz Cem, Yazar Fatih, Cavusoglu Ilkin

机构信息

Department of Histology & Embryology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

出版信息

Acta Oncol. 2003;42(1):71-4. doi: 10.1080/0891060310002267.

DOI:10.1080/0891060310002267

PMID:12665334

Abstract

Syndecan-1 (CD138), an important transmembrane heparan sulfate proteoglycan is expressed in distinct stages of cell differentiation. Although its expression in acute lymphoblastic leukemia (ALL) cells is well known: its function or presence in acute myeloblastic leukemia (AML) cells is still largely unknown. The expression of syndecan-1 was studied in bone marrow biopsies of three patients with AML using electron microscopic immunocytochemistry. Positive expression of syndecan-1 was found in AML cells. These results suggest that syndecan-1 expression is not only a characteristic phenotypic marker for ALL, but is also expressed in AML cells.

摘要

Syndecan-1（CD138）是一种重要的跨膜硫酸乙酰肝素蛋白聚糖，在细胞分化的不同阶段表达。尽管其在急性淋巴细胞白血病（ALL）细胞中的表达已为人所知，但其在急性髓细胞白血病（AML）细胞中的功能或存在情况仍大多未知。使用电子显微镜免疫细胞化学方法，对三名AML患者的骨髓活检组织中syndecan-1的表达进行了研究。在AML细胞中发现了syndecan-1的阳性表达。这些结果表明，syndecan-1的表达不仅是ALL的特征性表型标志物，也在AML细胞中表达。