[尿路致病性大肠杆菌菌株对抗生素、噬菌体及杀菌血清活性的敏感性]

[The sensitivity of the uropathogenic Escherichia coli strains to antibiotics, bacteriophages and bactericidal serum activity].

作者信息

Drulis-Kawa Zuzanna, Weber-Dabrowska Beata, Lewczyk Ewa, Jankowski Stanisław, Doroszkiewicz Włodzimierz

机构信息

Zakład Mikrobiologii Ogólnej, Instytut Mikrobiologii Uniwersytetu Wrocławskiego we Wrocławiu, Laboratorium Bakteriologiczne, Dolnoślaskie Centrum Pediatryczne im. J. Korczaka, Wrocławiu.

出版信息

Pol Merkur Lekarski. 2002 Dec;13(78):470-2.

PMID:12666443

Abstract

Escherichia coli strains isolated from children with urinary tract infections (UTI) were investigated for their sensitivity to antimicrobial drugs, bacteriophages and bactericidal activity of human serum. It has been proved, that the resistance to bactericidal effect of serum is not the dominant feature of uropathogenic Escherichia coli strains. Significant percentage of the strains appeared to be sensitive to the most popular drugs ordered during UTI treatment in children. No simple relationship between sensitivity of the strains to the drug and to the human serum has been found. Three of 44 bacteriophages specific to Escherichia coli have shown the lytic effect towards 50-60% strains under investigations.

摘要

对从患有尿路感染（UTI）的儿童中分离出的大肠杆菌菌株进行了研究，以检测它们对抗菌药物、噬菌体以及人血清杀菌活性的敏感性。已证实，对血清杀菌作用的抗性并非尿路致病性大肠杆菌菌株的主要特征。相当比例的菌株似乎对儿童UTI治疗期间最常用的药物敏感。未发现菌株对药物和人血清的敏感性之间存在简单关系。在44种大肠杆菌特异性噬菌体中，有3种对所研究的50%-60%的菌株显示出裂解作用。