[绝经后女性维生素D受体基因多态性与骨质疏松症关系的研究]
[Studies on the relationship between vitamin D receptor gene polymorphism and osteoporosis in postmenopausal women].
作者信息
Chen Jun, Zhang Liping, Qiu Junfeng, Peng Hui, Deng Zhongliang, Wang Yujun, Yan Zhongde
机构信息
Department of Endocrinology, the Second Teaching Hospital of Chongqing Medical University, Chongqing, 400010 P. R. China.
出版信息
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2003 Apr;20(2):167-8.
OBJECTIVE
To determine the relationship between vitamin D receptor (VDR) gene polymorphism and osteoporosis in postmenopausal women.
METHODS
The polymerase chain reaction-restriction fragment length polymorphism was used to detect VDR genotype in 40 patients with osteoporosis and 21 healthy postmenopausal women.
RESULTS
In the patients with osteoporosis, the bb, Bb, and BB genotype accounted for 82.5%, 17.5% and 0, respectively; in healthy groups, they were 85.71%, 14.29% and 0, respectively (P>0.05).
CONCLUSION
Significant association between VDR genotype and osteoporosis in Chinese women was observed in this study.
目的
确定维生素D受体（VDR）基因多态性与绝经后女性骨质疏松症之间的关系。
方法
采用聚合酶链反应-限制性片段长度多态性方法检测40例骨质疏松症患者和21例健康绝经后女性的VDR基因型。
结果
骨质疏松症患者中，bb、Bb和BB基因型分别占82.5%、17.5%和0；健康组中分别为85.71%、14.29%和0（P>0.05）。
结论
本研究未观察到中国女性VDR基因型与骨质疏松症之间存在显著关联。
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