Prettyman R
Department of Psychiatry for the Elderly, University of Leicester, The Bennion Centre, Glenfield General Hospital, Groby Road, Leicester LE3 9DZ, UK.
Age Ageing. 1998 Sep;27(5):557-60. doi: 10.1093/ageing/27.5.557.
to investigate the prevalence of extrapyramidal signs in elderly people and their relationship to disease.
151 non-demented subjects age 65 and over living within a defined geographical area in Nottingham who were participating in the MRC multicentre Cognitive Function and Ageing Study.
subjects were assessed at home. Extrapyramidal signs were rated according to a standardized neurological examination using items from the Unified Parkinson's Disease Rating Scale.
bradykinetic and hypokinetic abnormalities are a frequent finding, especially in the oldest old. Over 50% of subjects aged 80 or over demonstrated at least one such sign. Only 10% of subjects had any recorded neurological disease.
the frequency of recognized neurological and other disease is insufficient to account for the rate of subtle extrapyramidal abnormalities found. These findings may thus represent intrinsic age-related changes in neurological functioning, this being consistent with previously described pathological changes in the substantia nigra and striatum in normal ageing.
调查老年人锥体外系体征的患病率及其与疾病的关系。
151名年龄在65岁及以上、居住在诺丁汉特定地理区域内、参与医学研究委员会多中心认知功能与衰老研究的非痴呆受试者。
在家中对受试者进行评估。根据标准化神经学检查，使用统一帕金森病评定量表中的项目对锥体外系体征进行评分。
运动徐缓和运动减退异常很常见，尤其是在高龄老人中。80岁及以上的受试者中超过50%表现出至少一种此类体征。只有10%的受试者有任何记录在案的神经疾病。
已确认的神经疾病和其他疾病的发生率不足以解释所发现的轻微锥体外系异常的发生率。因此，这些发现可能代表了神经功能内在的与年龄相关的变化，这与先前描述的正常衰老过程中黑质和纹状体的病理变化一致。
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