Schäfer F K, Schäfer P J, Jahnke T, Walluscheck K, Priebe M, Hentsch A, Heller M, Brossmann J
Klinik für Diagnostische Radiologie an der Christian-Albrechts-Universität zu Kiel.
Rofo. 2003 Apr;175(4):556-64. doi: 10.1055/s-2003-38446.
To assess the value of contrast enhanced (CE)-MR angiography (MRA) with 1.0 molar Gadobutrol (Schering, Germany) in comparison to intraarterial DSA in peripheral arterial occlusive disease (PAOD).
Within 48 hours, 30 symptomatic patients with PAOD were examined by CE-MRA (Gadobutrol dose 0.2-0.3 mmol/kg body weight) and DSA. For CE-MRA, a 1.5 T magnet (Vision, Siemens, Germany) was used (FA 35 degrees, TR/TE 4.6/1.8 ms, FOV 400 mm, matrix 230 x 512, total acquisition time 81 sec). Two radiologists evaluated a total of 600 vessel segments for stenotic lesions and image quality (1 = not visible to 5 = excellent). Treatment was independently planned on the basis of the MRA and DSA findings.
The Kendall's tau-b coefficient was 0.92 for overall stenotic grading, and 0.92, 0.93 and 0.92, respectively, for the vascular flow in the iliac, femoropopliteal and crural arteries. Sensitivity, specificity, negative and positive predictive value, and accuracy were, respectively, 94, 97, 98 and 92, 96 % for > 50 % stenoses, 95, 99, 99, 95 and 99 % for iliac arteries, 96, 98, 98%, 94 and 97 % for femoropopliteal arteries, and 92, 94, 96, 89 and 94 % for crural arteries. Therapy planning by MRA and DSA coincided in 51 of 54 cases. No relevant adverse event occurred.
CE-MRA with 1.0 molar Gadobutrol is highly efficient in diagnosing peripheral arterial occlusive disease and correlates excellently with DSA.
评估使用1.0摩尔钆布醇（德国先灵公司）进行对比增强（CE）磁共振血管造影（MRA）在外周动脉闭塞性疾病（PAOD）中与动脉内数字减影血管造影（DSA）相比的价值。
在48小时内，对30例有症状的PAOD患者进行了CE-MRA（钆布醇剂量为0.2 - 0.3 mmol/kg体重）和DSA检查。对于CE-MRA，使用1.5 T磁体（德国西门子公司的Vision）（翻转角35度，重复时间/回波时间4.6/1.8 ms，视野400 mm，矩阵230×512，总采集时间81秒）。两名放射科医生对总共600个血管节段进行狭窄病变和图像质量评估（1 = 不可见至5 = 极佳）。根据MRA和DSA结果独立制定治疗方案。
总体狭窄分级的肯德尔tau-b系数为0.92，髂动脉、股腘动脉和小腿动脉的血流分级的肯德尔tau-b系数分别为0.92、0.93和0.92。对于>50%的狭窄，敏感性、特异性、阴性和阳性预测值以及准确性分别为94%、97%、98%和92%、96%；髂动脉分别为95%、99%、99%、95%和99%；股腘动脉分别为96%、98%、98%、94%和97%；小腿动脉分别为92%、94%、96%、89%和94%。MRA和DSA制定的治疗方案在54例中有51例一致。未发生相关不良事件。
使用1.0摩尔钆布醇的CE-MRA在诊断外周动脉闭塞性疾病方面效率很高，且与DSA相关性极佳。
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