Vlems F A, Wobbes Th, Punt C J A, Van Muijen G N P
Department of Surgery, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
Anticancer Res. 2003 Jan-Feb;23(1B):523-30.
In colorectal cancer, the predictive value of the currently used staging method is limited. Therefore, many parameters have been studied to improve the prediction of final clinical outcome, including several aspects of the primary tumor that are associated with its aggressiveness and the capacity of the host response. A more direct approach to predict the metastatic potential of a tumor may be the determination of limited disseminated disease at an early stage before it becomes clinically evident. Very sensitive techniques have been developed to detect single or very few tumor cells that have been disseminated into lymph nodes, blood, bone marrow and the peritoneal cavity. This review describes the advantages and disadvantages of the main detection techniques and discusses the current state of clinical relevance of disseminated tumor cells in patients with colorectal cancer.
在结直肠癌中，目前所使用的分期方法的预测价值有限。因此，人们研究了许多参数以改善对最终临床结局的预测，包括与原发性肿瘤侵袭性及其宿主反应能力相关的几个方面。预测肿瘤转移潜能的一种更直接方法可能是在临床明显之前的早期阶段确定局限性播散性疾病。已经开发出非常灵敏的技术来检测已播散到淋巴结、血液、骨髓和腹腔中的单个或极少数肿瘤细胞。这篇综述描述了主要检测技术的优缺点，并讨论了结直肠癌患者中播散性肿瘤细胞的临床相关性现状。
