某些抗惊厥药物对维生素B12缺乏饮食的大鼠体内叶酸消耗的影响。

Effect of some anticonvulsant drugs on depletion of folate in rats on a vitamin B12-deficient diet.

作者信息

Williams D L, Spray G H

出版信息

Br J Haematol. 1976 Jun;33(2):273-8. doi: 10.1111/j.1365-2141.1976.tb03538.x.

DOI:10.1111/j.1365-2141.1976.tb03538.x

Abstract

Rats fed on vitamin B12-deficient or vitamin B12-supplemented diets and treated with phenobarbitone by intraperitoneal injection for 5 d showed significant increases in the activity of glutamate formiminotransferase in liver. The only significant depletion in liver folate activity was in vitamin B12-supplemented rats that were starved for 48 h. When rats were given the same diets, with phenobarbitone and diphenylhydantoin added, for 12 weeks or more in two separate experiments, significant increases in transferase activity were found only in the livers of animals fed on the deficient diet. However, there was significant depletion of liver folate in animals taking the supplemented diet.

摘要

用缺乏维生素B12或补充了维生素B12的饲料喂养大鼠，并通过腹腔注射苯巴比妥处理5天，结果显示肝脏中谷氨酸亚胺甲基转移酶的活性显著增加。肝脏叶酸活性唯一显著降低的情况出现在补充了维生素B12且饥饿48小时的大鼠中。在两项独立实验中，当给大鼠喂食相同的饲料，并添加苯巴比妥和苯妥英钠，持续12周或更长时间时，仅在食用缺乏维生素B12饲料的动物肝脏中发现转移酶活性显著增加。然而，食用补充了维生素B12饲料的动物肝脏中叶酸有显著减少。