Notch/RBP-J信号通路对B细胞发育的调控

Regulation of B cell development by Notch/RBP-J signaling.

作者信息

Tanigaki Kenji, Kuroda Kazuki, Han Hua, Honjo Tasuku

机构信息

Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida-Konoe, Sakyo-Ku, Kyoto 606-8501, Japan.

出版信息

Semin Immunol. 2003 Apr;15(2):113-9. doi: 10.1016/s1044-5323(03)00008-3.

DOI:10.1016/s1044-5323(03)00008-3

PMID:12681948

Abstract

RBP-J is an essential signal mediator of all four Notches in nuclei. Loss-of-function analyses clearly show the crucial roles of RBP-J in commitment of T cells versus B cells as well as MZ B cells versus Fo B cells. Such Notch/RBP-J regulation of dichotomic differentiation steps in lymphocyte is reminiscent of the development of sensory organ precursors (SOPs) in Drosophila. Studies on RBP-J conditional knockout mice that have lost MZ B cells without affecting Fo B cell functions have shown that MZ B cells play pivotal roles in immune responses to blood-borne bacteria.

摘要

RBP-J是细胞核中所有四种Notch信号的重要介导因子。功能丧失分析清楚地表明RBP-J在T细胞与B细胞以及边缘区B细胞与滤泡B细胞的分化过程中起着关键作用。淋巴细胞二分分化步骤中的这种Notch/RBP-J调节让人联想到果蝇感觉器官前体（SOP）的发育。对RBP-J条件性敲除小鼠的研究表明，边缘区B细胞在对血源细菌的免疫反应中起关键作用，这些小鼠失去了边缘区B细胞，但不影响滤泡B细胞的功能。