β2-肾上腺素能受体基因多态性与老年人发生心血管事件的风险

Beta2-adrenergic receptor polymorphisms and risk of incident cardiovascular events in the elderly.

作者信息

Heckbert Susan R, Hindorff Lucia A, Edwards Karen L, Psaty Bruce M, Lumley Thomas, Siscovick David S, Tang Zhonghua, Durda J Peter, Kronmal Richard A, Tracy Russell P

机构信息

Department of Epidemiology, University of Washington, Seattle, USA.

出版信息

Circulation. 2003 Apr 22;107(15):2021-4. doi: 10.1161/01.CIR.0000065231.07729.92. Epub 2003 Apr 7.

DOI:10.1161/01.CIR.0000065231.07729.92

PMID:12682000

Abstract

BACKGROUND

Genetic polymorphisms at codons 16 and 27 of the beta2-adrenergic receptor have been associated with altered response to sympathetic stimulation. We examined these polymorphisms in relation to cardiovascular event risk in the Cardiovascular Health Study.

METHODS AND RESULTS

A total of 808 black and 4441 white participants (mean age, 73 years) were genotyped for the Arg16Gly and Gln27Glu polymorphisms of the beta2-adrenergic receptor. There were 702 incident coronary events, 438 ischemic strokes, and 1136 combined cardiovascular events during 7 to 10 years of follow-up. Allele frequencies differed by race but not by age or hypertension status. Glu27 carriers had a lower risk of coronary events than Gln27 homozygotes (hazard ratio, 0.82; 95% CI, 0.70 to 0.95), and there was a suggestion of decreased risk among Gly16 carriers compared with Arg16 homozygotes (hazard ratio, 0.88; 95% CI, 0.72 to 1.07). There was no association of beta2-adrenergic receptor genotype with ischemic stroke or combined cardiovascular events.

CONCLUSIONS

The Glu27 allele of the beta2-adrenergic receptor was associated with a lower risk of incident coronary events in this elderly population.

摘要

背景

β2 - 肾上腺素能受体第16和27密码子的基因多态性与对交感神经刺激的反应改变有关。我们在心血管健康研究中研究了这些多态性与心血管事件风险的关系。

方法与结果

对总共808名黑人参与者和4441名白人参与者（平均年龄73岁）进行了β2 - 肾上腺素能受体的Arg16Gly和Gln27Glu多态性基因分型。在7至10年的随访期间，发生了702例冠心病事件、438例缺血性中风和1136例合并心血管事件。等位基因频率因种族而异，但不因年龄或高血压状态而异。Glu27携带者发生冠心病事件的风险低于Gln27纯合子（风险比，0.82；95%可信区间，0.70至0.95），并且与Arg16纯合子相比，Gly16携带者的风险有降低的趋势（风险比，0.88；95%可信区间，0.72至1.07）。β2 - 肾上腺素能受体基因型与缺血性中风或合并心血管事件无关联。