7-羟基-2-取代甲基-5H-恶唑并[3,2-a]嘧啶-5-酮衍生物的抗白血病活性
Anti-leukemia activity of 7-hydroxy-2-substituted-methyl-5H-oxazolo[3,2-a]pyrimidin-5-one derivatives.
作者信息
Guillon Jean, Mamani-Matsuda Maria, Massip Stephane, Leger Jean-Michel, Thiolat Denis, Mossalayi Djavad, Jarry Christian
机构信息
EA 2962-Pharmacochimie, Université Victor Segalen Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux cedex, France.
出版信息
J Enzyme Inhib Med Chem. 2002 Dec;17(6):391-6. doi: 10.1080/1475636021000005668.
PMID:12683674
Abstract
The synthesis of new 7-hydroxy-2-substituted-methyl-5H-oxazolo[3,2-a]pyrimidin-5-ones derivatives, designed as structural bicyclic analogues of the iron chelator deferiprone, is described. They were tested for their ability to inhibit proliferation in human Bcr-Abl+ leukemia cells.
摘要
本文描述了新型7-羟基-2-取代甲基-5H-恶唑并[3,2-a]嘧啶-5-酮衍生物的合成，该衍生物被设计为铁螯合剂去铁酮的双环结构类似物。对它们抑制人Bcr-Abl+白血病细胞增殖的能力进行了测试。
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