向小鼠脑室内注射神经肽Y可刺激抵抗素基因表达。

Intracerebroventricular administration of NPY stimulates resistin gene expression in mice.

作者信息

Yuzuriha Hideki, Inui Akio, Goto Kyoko, Asakawa Akihiro, Fujimiya Mineko, Kasuga Masato

机构信息

Division of Diabetes, Digestive and kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Japan.

出版信息

Int J Mol Med. 2003 May;11(5):675-6.

PMID:12684710

Abstract

Resistin is thought to cause insulin resistance and link obesity to type 2 diabetes mellitus. However, little is known about the effects of neuropeptide Y (NPY) on resistin gene expression in white adipose tissue (WAT). Resistin gene expression was determined by northern blot analysis in food-deprived mice after NPY administration. Administered NPY (1 nmol/mouse) significantly increased resistin mRNA expression in WAT by 72% compared with artificial cerebrospinal fluid treated controls. These observations indicate that NPY might have a role in regulating resistin gene expression in WAT and that the novel brain-fat axis might be involved in the pathogenesis of obesity and related diseases.

摘要

抵抗素被认为会导致胰岛素抵抗，并将肥胖与2型糖尿病联系起来。然而，关于神经肽Y（NPY）对白色脂肪组织（WAT）中抵抗素基因表达的影响，人们所知甚少。通过Northern印迹分析确定了给予NPY后食物剥夺小鼠中抵抗素基因的表达。与人工脑脊液处理的对照组相比，给予的NPY（1 nmol/小鼠）使WAT中抵抗素mRNA表达显著增加了72%。这些观察结果表明，NPY可能在调节WAT中抵抗素基因表达方面发挥作用，并且新的脑-脂肪轴可能参与肥胖及相关疾病的发病机制。