Key personalities in the development and popularization of the transsphenoidal approach to pituitary tumors: an historical overview.

Although the transsphenoidal procedure, as we know it today, was devised at the beginning of the last century, its acceptance and eventual widespread affirmation have been a slow but relentless process. Like many technologic and scientific advances, several individuals contributed to the perfection of an idea whose time had come. Yet, it is unequivocally accepted that a few key figures played a critical role in the development, preservation, and eventual widespread popularization of transsphenoidal surgery. These pioneers were original thinkers and bold (albeit careful) surgeons. Their persistence in the face of incredible obstacles provides a source of continuous inspiration.