Sridhar G R
Endocrine and Diabetes Centre, 15-12-16 Krishnanagar, Visakhapatnam, 530 002.
J Assoc Physicians India. 2003 Jan;51:49-52.
Peroxisome proliferator-activated receptors (PPAR) are a family of nuclear receptors that regulate lipid and carbohydrate metabolism in response to extracellular fatty acids and their metabolites. They are crucial in the regulation of fat storage, besides having a potential role in insulin resistance syndrome. They have clinical relevance in understanding the cause and in development of drugs in common clinical conditions such as type 2 diabetes mellitus, cellular growth and neoplasia. Three types of receptors were identified: PPAR alpha, gamma and delta. Fibrate group of lipid lowering agents bind to the alpha isoform and glitazone group of insulin sensitizers to gamma isoform. Further advances can result in new drugs for atherosclerosis, malignancies and diabetes mellitus.
过氧化物酶体增殖物激活受体（PPAR）是一类核受体，可响应细胞外脂肪酸及其代谢产物调节脂质和碳水化合物代谢。它们在脂肪储存的调节中至关重要，此外在胰岛素抵抗综合征中也可能发挥作用。它们在理解2型糖尿病、细胞生长和肿瘤形成等常见临床病症的病因及药物研发方面具有临床相关性。已鉴定出三种类型的受体：PPARα、γ和δ。贝特类降脂药物与α亚型结合，而胰岛素增敏剂格列酮类与γ亚型结合。进一步的进展可能会带来用于治疗动脉粥样硬化、恶性肿瘤和糖尿病的新药。
