van Sorge N M, van der Pol W-L, van de Winkel J G J
Immunology/Neurology, UMC, Utrecht, the Netherlands.
Tissue Antigens. 2003 Mar;61(3):189-202. doi: 10.1034/j.1399-0039.2003.00037.x.
Leukocyte Fcgamma receptors (FcgammaR) confer potent cellular effector functions to the specificity of IgG. FcgammaR-induced leukocyte functions, including antibody-dependent cellular cytotoxicity, phagocytosis, superoxide generation, degranulation, cytokine production and regulation of antibody production, are essential for host defense and immune regulation. The efficacy of IgG-induced FcgammaR function displays inter-individual heterogeneity due to genetic polymorphisms of three FcgammaR subclasses, FcgammaRIIa (CD32a), FcgammaRIIIa (CD16a), and FcgammaRIIIb (CD16b). FcgammaR polymorphisms have been associated with infectious and autoimmune disease, or with disease severity. FcgammaR polymorphisms may furthermore serve as markers for therapeutic efficacy and side-effects of treatment with monoclonal antibodies. In this review, FcgammaR function and the relevance of FcgammaR polymorphisms as prognostic markers for inflammatory disease and antibody-based immunotherapy are discussed.
白细胞Fcγ受体（FcγR）赋予IgG特异性强大的细胞效应功能。FcγR诱导的白细胞功能，包括抗体依赖性细胞毒性、吞噬作用、超氧化物生成、脱颗粒、细胞因子产生以及抗体产生的调节，对于宿主防御和免疫调节至关重要。由于三种FcγR亚类，即FcγRIIa（CD32a）、FcγRIIIa（CD16a）和FcγRIIIb（CD16b）的基因多态性，IgG诱导的FcγR功能的效力存在个体间异质性。FcγR多态性与感染性和自身免疫性疾病或疾病严重程度相关。此外，FcγR多态性还可作为单克隆抗体治疗疗效和副作用的标志物。在本综述中，将讨论FcγR功能以及FcγR多态性作为炎症性疾病和基于抗体的免疫治疗预后标志物的相关性。
