Horii Toshinobu, Morita Motoki, Muramatsu Hideaki, Muranaka Yoshinori, Kanno Takashi, Maekawa Masato
Department of Laboratory Medicine and Group of Infection Control Research, Hamamatsu University School of Medicine, 1-20-1 Handa-yama, Hamamatsu 431-3192, Japan.
J Antimicrob Chemother. 2003 May;51(5):1175-9. doi: 10.1093/jac/dkg226. Epub 2003 Apr 14.
Colonization of Pseudomonas aeruginosa at trachea, nares and oropharynx can cause ventilator-acquired pneumonia. To identify beneficial effects of antibiotics on expression of virulence factors related to colonization by such pathogens, we evaluated the effect of mupirocin on flagella formation in P. aeruginosa and on motility and flagella formation in Proteus mirabilis. In P. aeruginosa, subinhibitory concentrations of mupirocin inhibited flagella formation, which was associated with reduced flagellin expression. In P. mirabilis, subinhibitory concentrations of mupirocin dose-dependently suppressed bacterial motility and flagella formation, again with reduced flagellin expression. Our results indicate that subinhibitory concentrations of mupirocin can suppress expression of virulence factors in P. aeruginosa and P. mirabilis.
铜绿假单胞菌在气管、鼻腔和口咽部的定植可导致呼吸机相关性肺炎。为了确定抗生素对这类病原体定植相关毒力因子表达的有益作用，我们评估了莫匹罗星对铜绿假单胞菌鞭毛形成以及奇异变形杆菌运动性和鞭毛形成的影响。在铜绿假单胞菌中，亚抑菌浓度的莫匹罗星抑制鞭毛形成，这与鞭毛蛋白表达降低有关。在奇异变形杆菌中，亚抑菌浓度的莫匹罗星剂量依赖性地抑制细菌运动性和鞭毛形成，同样伴有鞭毛蛋白表达降低。我们的结果表明，亚抑菌浓度的莫匹罗星可抑制铜绿假单胞菌和奇异变形杆菌中毒力因子的表达。
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