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弹性Y型模型中的实验流动研究。

Experimental flow studies in an elastic Y-model.

作者信息

Mijovic Budimir, Liepsch Dieter

机构信息

Laboratory for Biofluid Mechanics, University of Applied Sciences, Munich, Germany.

出版信息

Technol Health Care. 2003;11(2):115-41.

Abstract

To determine the causes and history of atherosclerosis it is necessary to understand the hemodynamic parameters of blood circulation. Hemodynamic parameters play an important role in the formation of atherosclerotic plaques, especially near bends and bifurcations where the flow separates from the wall. Here the flow is laminar and non-axial with eddies, secondary flow, flow separation and stagnation points. Stenoses are found predominantly in flow separation areas. Therefore, it is important to separately study the following flow parameters: steady and pulsatile flow, wall elasticity and non-Newtonian flow behavior of blood. A simplified silicon elastic y-model simulating the human carotid artery was used for the analysis of these parameters. This model can be used for numerical studies as well. Flow was visualized at steady flow using dyes and at pulsatile flow with a photoelastic apparatus and a birefringent solution. The local axial velocity at steady and pulsatile flow was determined with a one-component Laser-Doppler-Anemometer (LDA). Pulsatile flow was generated by a piston membrane pump. A glycerin-water solution was used to simulate the Newtonian flow behavior of blood. A DMSO-Separan water solution was used to simulate the non-Newtonian flow behavior. Pulsatile flow creates higher and lower shear rates so called oscillating shear rate compare to steady flow depending on the velocity amplitude. The non-Newtonian fluid showed a markedly different flow behavior than the Newtonian fluid especially in areas of flow separation. Shear gradients were calculated from these velocity measurements using a bicubic spline interpolation. Shear stresses were calculated from these velocity shear gradients and the viscosity of the non-Newtonian fluid at these shear gradients. At special areas, high shear stresses > 10 Pa were found. The elasticity of the model wall also influences the flow behavior. The measurements showed that the characteristics of pulsatile flow and the elasticity of the model wall should be observed concomitantly. This paper presents the steady and pulsatile flow with a Newtonian and non-Newtonian fluid in an elastic model.

摘要

为了确定动脉粥样硬化的病因和病史,有必要了解血液循环的血流动力学参数。血流动力学参数在动脉粥样硬化斑块的形成中起着重要作用,特别是在血流从血管壁分离的弯曲和分叉处附近。此处的血流是层流且非轴向的,伴有涡流、二次流、血流分离和停滞点。狭窄主要出现在血流分离区域。因此,分别研究以下血流参数很重要:稳定流和脉动流、血管壁弹性以及血液的非牛顿流动行为。使用一个简化的模拟人体颈动脉的硅弹性y模型来分析这些参数。该模型也可用于数值研究。在稳定流时使用染料使血流可视化,在脉动流时使用光弹性装置和双折射溶液。用单分量激光多普勒测速仪(LDA)测定稳定流和脉动流时的局部轴向速度。脉动流由活塞膜泵产生。使用甘油 - 水溶液模拟血液的牛顿流动行为。使用二甲基亚砜 - 西帕兰水溶液模拟非牛顿流动行为。与稳定流相比,脉动流会产生更高和更低的剪切速率,即所谓的振荡剪切速率,这取决于速度幅度。非牛顿流体与牛顿流体表现出明显不同的流动行为,特别是在血流分离区域。使用双三次样条插值从这些速度测量值计算剪切梯度。根据这些速度剪切梯度和非牛顿流体在这些剪切梯度下的粘度计算剪切应力。在特殊区域发现了大于10 Pa的高剪切应力。模型壁的弹性也会影响流动行为。测量结果表明,应同时观察脉动流的特性和模型壁的弹性。本文介绍了在弹性模型中牛顿流体和非牛顿流体的稳定流和脉动流。

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