Saito Naoto, Takaoka Kunio
Department of Orthopaedic Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan.
Biomaterials. 2003 Jun;24(13):2287-93. doi: 10.1016/s0142-9612(03)00040-1.
Bone morphogenetic proteins (BMPs) are biologically active molecules capable of inducing new bone formation and are expected to be used clinically in combination with biomaterials such as bone-graft substitutes to promote bone repair. The carrier materials for BMPs have to not only secure the BMPs in the local area and diffuse them afterwards, but also to provide scaffolding for the newly formed bone. Since synthetic, biodegradable polymers with optimal properties are considered most desirable, we synthesized polylactic acid and its derivatives. Some of these were found to consistently induce ectopic bone formation when combined with BMP and implanted into the muscles of experimental animals. It was also found that the three-dimensional configuration of BMP-induced bone mass could be controlled. This means that our attempt to construct synthetic biomaterials which can induce controllable bone formation was successful.
骨形态发生蛋白（BMPs）是能够诱导新骨形成的生物活性分子，有望与骨移植替代物等生物材料联合用于临床，以促进骨修复。BMPs的载体材料不仅必须将BMPs固定在局部区域并随后使其扩散，还必须为新形成的骨提供支架。由于具有最佳性能的合成可生物降解聚合物被认为是最理想的，我们合成了聚乳酸及其衍生物。当将其中一些与BMP联合并植入实验动物的肌肉中时，发现它们能持续诱导异位骨形成。还发现可以控制BMP诱导骨量的三维构型。这意味着我们构建能够诱导可控骨形成的合成生物材料的尝试是成功的。
