Theokli Christopher, Morsi El-Kadi Ali S, Morgan Richard
Department of Anatomy and Developmental Biology, St. George's Hospital Medical School, London, United Kingdom.
Dev Dyn. 2003 May;227(1):48-55. doi: 10.1002/dvdy.10287.
The Hox genes are a family of homeodomain-containing transcription factors that determine anteroposterior identity early on in development. Although much is now known about their regulation and function, very little is known of their effector (downstream target) genes. Here, we show that the TALE class homeodomain transcription factor Irx5 is a direct, positively regulated target of Hoxb4.
Hox基因是一类包含同源结构域的转录因子家族,在发育早期决定前后轴身份。尽管目前对其调控和功能已了解很多,但对其效应器(下游靶标)基因却知之甚少。在此,我们表明TALE类同源结构域转录因子Irx5是Hoxb4的直接正向调控靶标。