Thomas-Gibson Siwan, Brooker Jim C, Hayward Christopher M M, Shah Syed G, Williams Christopher B, Saunders Brian P
Wolfson Unit for Endoscopy, St Mark's Hospital, London, UK.
Eur J Gastroenterol Hepatol. 2003 May;15(5):485-8. doi: 10.1097/01.meg.0000059110.41030.bc.
To study the long-term outcomes of patients who have had endoscopic balloon dilation of Crohn's strictures.
Retrospective case-note review over a 16-year period.
Patients with a Crohn's stricture causing obstructive symptoms and who had at least 6 months' follow-up data or a surgical outcome following dilation were sought; 59 patients (124 dilations) were identified.
Patients all underwent endoscopic balloon dilation.
Strictures were anastomotic in 53 patients (111 dilations) and de novo in six patients (13 dilations). The median stricture length was 3.0 cm. Median follow-up time was 29.4 months. Out of the total group, 41% of patients achieved long-term clinical benefit following dilation and in 17% after only a single dilation. The median number of dilations per patient was one. A total of 35 (59%) patients required surgery for their stricture during follow-up. There were two (1.6%) perforations as a result of dilation, one in an anastomotic stricture (managed conservatively) and one in a de-novo stricture (requiring surgery). There were no deaths.
Colonoscopic balloon dilation of Crohn's strictures can achieve long-term clinical benefit in many patients. Repeat dilations are justified in initial non-responders. In this series, the procedure appears safe with low morbidity.
研究克罗恩狭窄患者接受内镜下球囊扩张术的长期疗效。
对16年期间的病例记录进行回顾性研究。
寻找患有导致梗阻症状的克罗恩狭窄且有至少6个月随访数据或扩张术后手术结果的患者;共识别出59例患者(124次扩张)。
所有患者均接受内镜下球囊扩张术。
53例患者(111次扩张)的狭窄为吻合口狭窄,6例患者(13次扩张)为原发性狭窄。狭窄的中位长度为3.0厘米。中位随访时间为29.4个月。在整个研究组中,41%的患者在扩张后获得了长期临床益处,17%的患者仅在单次扩张后即获得益处。每位患者的扩张中位次数为1次。共有35例(59%)患者在随访期间因狭窄需要手术治疗。扩张导致2例(1.6%)穿孔,1例发生在吻合口狭窄(保守治疗),1例发生在原发性狭窄(需要手术)。无死亡病例。
结肠镜下球囊扩张术可使许多克罗恩狭窄患者获得长期临床益处。对于初始无反应者,重复扩张是合理的。在本系列研究中,该手术似乎安全,发病率低。