von Känel Roland, Dimsdale Joel E
Institute for Behavioral Sciences, Swiss Federal Institute of Technology, Zürich, Switzerland.
Clin Cardiol. 2003 Apr;26(4):164-8. doi: 10.1002/clc.4960260403.
Psychosocial factors might mediate their adverse impact on coronary arteries by eliciting a hypercoagulable state via changes in sympathetic nervous system activity. A recent meta-analysis of prospective studies reported an association of the hypercoagulability marker D-dimer with an increased risk for coronary events. This review provides evidence that an elevated plasma D-dimer level is a suitable marker for acute and chronic psychosocial distress. Prospective studies need to show whether stress-related changes in D-dimer may help explain the increased coronary risk with psychosocial distress.
心理社会因素可能通过交感神经系统活动的变化引发高凝状态,从而介导其对冠状动脉的不利影响。最近一项对前瞻性研究的荟萃分析报告称,高凝标志物D-二聚体与冠状动脉事件风险增加有关。这篇综述提供了证据,表明血浆D-二聚体水平升高是急性和慢性心理社会应激的合适标志物。前瞻性研究需要表明,与压力相关的D-二聚体变化是否有助于解释心理社会应激导致的冠状动脉风险增加。