卵巢癌的肿瘤细胞减灭术

Cytoreductive surgery for ovarian cancer.

作者信息

Kecmanovic D M, Pavlov M J, Kovacevic P A, Ceranic M S, Stamenkovic A B

机构信息

Department for Colorectal Surgery, First Surgical University Hospital, Clinical Center of Serbia, Koste Todorovica 6, Belgrade, Serbia, Yugoslavia.

出版信息

Eur J Surg Oncol. 2003 May;29(4):315-20. doi: 10.1053/ejso.2002.1367.

DOI:10.1053/ejso.2002.1367

PMID:12711282

Abstract

AIM

The aim of this study is to describe the technique of managing peritoneal dissemination in patients with ovarian cancer, based on radical surgical excision and, later, perioperative chemotherapy.

METHOD

Treatments included complete surgical resection of the peritoneal disease, and intraperitoneal intraoperative and postoperative chemotherapy, using Adriamycin intraoperatively, and Cis-platinol next 1-5 postoperative days.

RESULTS

Eleven cytoreductive procedures were performed between 1996 and 2002. Eight patients with primary ovarian cancer underwent total hysterectomy with bilateral adnexectomy, omentectomy and peritonectomy of the pelvic cavity. In 3 cases with recurrent ovarian cancer, peritonectomy alone was performed. Bowel resection was performed in all patients. The median operation time was 279 min (range 190-500min). Median total blood loss was 919 mL (range 450-1330 mL). The median survival time was 22 months.

CONCLUSION

Cytoreductive procedure offers satisfactory results in peritoneal carcinomatosis in patients with advanced primary ovarian cancer.

摘要

目的

本研究旨在描述基于根治性手术切除及后续围手术期化疗来处理卵巢癌患者腹膜播散的技术。

方法

治疗包括对腹膜疾病进行完整的手术切除，以及术中及术后进行腹腔内化疗，术中使用阿霉素，术后第1 - 5天使用顺铂。

结果

1996年至2002年间进行了11例肿瘤细胞减灭术。8例原发性卵巢癌患者接受了全子宫切除加双侧附件切除术、大网膜切除术及盆腔腹膜切除术。3例复发性卵巢癌患者仅进行了腹膜切除术。所有患者均进行了肠切除术。中位手术时间为279分钟（范围190 - 500分钟）。中位总失血量为919毫升（范围450 - 1330毫升）。中位生存时间为22个月。