Gerlt John A, Raushel Frank M
Department of Biochemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA.
Curr Opin Chem Biol. 2003 Apr;7(2):252-64. doi: 10.1016/s1367-5931(03)00019-x.
The (beta/alpha)(8)-barrel is the most common fold in structurally characterized enzymes. Whether the functionally diverse enzymes that share this fold are the products of either divergent or convergent evolution (or both) is an unresolved question that will probably be answered as the sequence databases continue to expand. Recent work has examined natural, designed, and directed evolution of function in several superfamilies of (beta/alpha)(8)-barrel containing enzymes.
β/α（8）桶状结构是已确定结构的酶中最常见的折叠形式。具有这种折叠形式但功能各异的酶是趋异进化、趋同进化（或两者兼有）的产物，这一尚未解决的问题可能会随着序列数据库的不断扩充而得到解答。最近的研究工作已对含有β/α（8）桶状结构的酶的几个超家族中功能的自然进化、设计进化和定向进化进行了研究。
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