Ai Julia, Leonhardt Janie M, Heymann Warren R
University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Camden, USA.
J Am Acad Dermatol. 2003 May;48(5):641-59; quiz 660-2. doi: 10.1067/mjd.2003.257.
Autoimmune thyroid disease (AITD) including Graves' disease, Hashimoto's thyroiditis, and idiopathic hypothyroidism (atrophic Hashimoto's thyroiditis) is of vital concern to the dermatologist. This article reviews the cutaneous manifestations of Graves' disease and Hashimoto's thyroiditis. Recognition of dermatologic manifestations of AITD may alert practitioners to investigate for these disorders. The immune response involved in the pathogenesis of AITD is detailed. Current understanding of the role of genetic and environmental factors, antigens, and apoptosis are elaborated. The future holds exciting insight into the etiology, pathogenesis, and treatment of AITD.
自身免疫性甲状腺疾病(AITD),包括格雷夫斯病、桥本甲状腺炎和特发性甲状腺功能减退症(萎缩性桥本甲状腺炎),是皮肤科医生至关重要的关注点。本文综述了格雷夫斯病和桥本甲状腺炎的皮肤表现。认识到AITD的皮肤表现可能会提醒从业者对这些疾病进行调查。详细阐述了AITD发病机制中涉及的免疫反应。对遗传和环境因素、抗原及细胞凋亡的作用的当前理解也进行了阐述。未来对AITD的病因、发病机制和治疗有着令人兴奋的见解。