布尔盖宁F和布尔盖宁G的全合成。

Total synthesis of buergerinin F and buergerinin G.

作者信息

Han Jeong-Seok, Lowary Todd L

机构信息

Department of Chemistry, The Ohio State University, Columbus 43210, USA.

出版信息

J Org Chem. 2003 May 16;68(10):4116-9. doi: 10.1021/jo0341620.

DOI:10.1021/jo0341620

PMID:12737605

Abstract

Syntheses of buergerinin F (1) and buergerinin G (2) were carried out to establish the absolute stereochemistry of these natural products. A linear sequence was used to synthesize 1 in 15 steps and 9% overall yield from thymidine. Subsequent oxidation of 1 with ruthenium tetroxide afforded 2 in 77% yield.

摘要

进行了布尔盖林F（1）和布尔盖林G（2）的合成，以确定这些天然产物的绝对立体化学。采用线性合成路线，以胸苷为原料，经过15步反应，总产率为9%，合成了1。随后，用四氧化钌对1进行氧化，得到2，产率为77%。