染色体分离：抑制异常取向。

Chromosome segregation: clamping down on deviant orientations.

作者信息

Pidoux Alison, Allshire Robin

机构信息

Welcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, King's Buildings, UK.

出版信息

Curr Biol. 2003 May 13;13(10):R385-7. doi: 10.1016/s0960-9822(03)00316-6.

DOI:10.1016/s0960-9822(03)00316-6

PMID:12747847

Abstract

Chromosome segregation depends on proper orientation of sister kinetochores. The protein Csm1 is required for mono-orientation of sister kinetochores at meiosis I in budding yeast. Surprisingly, its homologue in fission yeast appears instead of clamp micro-tubule binding sites together on single mitotic kinetochores so that they all face one spindle pole.

摘要

染色体分离依赖于姐妹动粒的正确定向。在芽殖酵母减数分裂I中，蛋白质Csm1是姐妹动粒单定向所必需的。令人惊讶的是，它在裂殖酵母中的同源物却出现在单个有丝分裂动粒上，与夹微管结合位点一起，使它们都朝向一个纺锤极。