Fendrich V, Ramaswamy A, Nies C
Klinik für Visceral-,Thorax- und Gefässchirurgie, Philipps-Universität marburg.
Chirurg. 2003 May;74(5):473-7. doi: 10.1007/s00104-003-0622-x.
Primary aldosteronism is known to be caused by aldosterone-producing adenoma (APA). Total adrenalectomy is the standard procedure. In contrast to bilateral adrenal diseases (e.g., MEN II pheochromocytomas), there is no consensus about the effect of subtotal adrenalectomy.
A 44-year-old patient with primary aldosteronism caused by APA underwent subtotal adrenalectomy including removal of one adenoma. Because hypertension and hypokalemia did not disappear and hyperaldosteronism persisted, the patient had to undergo reoperation in which the adrenalectomy was completed.
Subtotal adrenalectomy in patients with Conn's syndrome is an interesting therapeutic option,whereas its effect is much higher in hereditary diseases of the adrenal gland. The benefit of preserved adrenal tissue has to be weighed against a possible persistence of hyperaldosteronism, especially in cases with normal opposite adrenal glands.
原发性醛固酮增多症已知由醛固酮分泌腺瘤(APA)引起。肾上腺全切术是标准手术。与双侧肾上腺疾病(如MEN II型嗜铬细胞瘤)不同,关于肾上腺次全切除术的效果尚无共识。
一名由APA引起原发性醛固酮增多症的44岁患者接受了肾上腺次全切除术,包括切除一个腺瘤。由于高血压和低钾血症未消失且醛固酮增多症持续存在,该患者不得不接受再次手术,完成了肾上腺切除术。
Conn综合征患者的肾上腺次全切除术是一种有趣的治疗选择,而其在肾上腺遗传性疾病中的效果要高得多。保留肾上腺组织的益处必须与醛固酮增多症可能持续存在相权衡,尤其是在对侧肾上腺正常的情况下。