人类转移性肝肿瘤中血管内皮生长因子、碱性成纤维细胞生长因子和内皮抑素的血清水平。

Serum levels of vascular endothelial growth factor, basic fibroblast growth factor and endostatin in human metastatic liver tumors.

作者信息

Miyashita Masao, Tajiri Takashi, Yanagi Ken, Shimizu Tetsuya, Futami Ryohei, Sasajima Koji, Tokunaga Akira

机构信息

Department of Surgery 1, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan.

出版信息

Hepatogastroenterology. 2003 Mar-Apr;50(50):308-9.

PMID:12749209

Abstract

BACKGROUND/AIMS: Angiogenic factors are related to the malignant potential of tumors. This study aimed to investigate the relationship of serum angiogenic factors to liver metastasis.

METHODOLOGY

The serum levels of vascular endothelial growth factor, basic fibroblast growth factor and endostatin were measured using EIA in 25 patients with metastatic liver tumors and were compared with those of 12 cancer patients without metastasis and 15 controls.

RESULTS

The serum vascular endothelial growth factor concentration was significantly higher in the liver metastasis group (503 +/- 84 pg/mL) than in the no metastasis group (205 +/- 38 pg/mL) and the control group (201 +/- 26 pg/mL). The three groups had similar serum basic fibroblast growth factor concentrations. There was no significant difference in serum levels of endostatin among the liver metastasis group (18.8 +/- 1.5 ng/mL), the no metastasis group (23.9 +/- 4.9 ng/mL), and the control group (17.1 +/- 1.5 ng/mL).

CONCLUSIONS

Angiogenic response is more prominent than anti-angiogenic responses in liver metastasis. These findings support the rationale for anti-angiogenesis therapy such as endostatin therapy in patients with liver metastasis.

摘要

背景/目的：血管生成因子与肿瘤的恶性潜能相关。本研究旨在探讨血清血管生成因子与肝转移之间的关系。

方法

采用酶免疫分析法（EIA）检测25例肝转移瘤患者血清中血管内皮生长因子、碱性成纤维细胞生长因子和内皮抑素的水平，并与12例无转移的癌症患者及15例对照组进行比较。

结果

肝转移组血清血管内皮生长因子浓度（503±84 pg/mL）显著高于无转移组（205±38 pg/mL）和对照组（201±26 pg/mL）。三组血清碱性成纤维细胞生长因子浓度相似。肝转移组（18.8±1.5 ng/mL）、无转移组（23.9±4.9 ng/mL）和对照组（17.1±1.5 ng/mL）血清内皮抑素水平无显著差异。