曲古抑菌素A的酰胺类似物：合成、结合模式分析及组蛋白去乙酰化酶抑制作用
Amide analogues of TSA: synthesis, binding mode analysis and HDAC inhibition.
作者信息
Van Ommeslaeghe K, Elaut G, Brecx V, Papeleu P, Iterbeke K, Geerlings P, Tourwé D, Rogiers V
机构信息
Department of Organic Chemistry, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium.
出版信息
Bioorg Med Chem Lett. 2003 Jun 2;13(11):1861-4. doi: 10.1016/s0960-894x(03)00284-1.
The synthesis of new amide type histone deacetylase inhibitors is described, having an (R)-methyl substituent and a diene or saturated structure of the chain linking the hydroxamic acid and dimethylaminobenzoyl groups. The saturated compound shows stronger HDAC inhibition than the unsaturated analogue. Molecular modeling suggests that the flexibility of the linker chain is important for an optimal orientation of the dimethylaminobenzoyl group in the enzyme.
描述了新型酰胺型组蛋白去乙酰化酶抑制剂的合成，其具有(R)-甲基取代基以及连接异羟肟酸和二甲基氨基苯甲酰基的链的二烯或饱和结构。饱和化合物显示出比不饱和类似物更强的HDAC抑制作用。分子模拟表明，连接链的灵活性对于二甲基氨基苯甲酰基在酶中的最佳取向很重要。
Zotero 插件