Vander Straten Melody R, Hossain Mohammad A, Ghannoum Mahmoud A
Department of Dermatology, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH, USA.
Infect Dis Clin North Am. 2003 Mar;17(1):87-112. doi: 10.1016/s0891-5520(02)00065-x.
Cutaneous fungal infections cause significant morbidity for healthy and ill patients. The incidence of some dermatomycoses is increasing, despite availability of newer and better topical and systemic treatments. Fungal remnants last months to years under the ideal conditions, allowing continued spread of infection. Mycoses treated in one area may recur because of organism travel from concomitant areas of infection. Failure of patients and physicians to recognize a fungal etiology early may lead to more extensive, severe, or difficult-to-treat infections. Finally, a patient's concurrent illnesses may play a part in susceptibility and ability to manage fungal infections. For these reasons, scientists have studied and developed newer antifungal agents with better efficacy and greater convenience in dosing. These drugs, however, still have side effects and medication interactions that may limit their use in some patients. Better efforts to educate patients and physicians alike may aid in faster recognition and treatment of dermatophytoses. More research is needed to continue to develop drugs suitable for use in a broader range of patients and diagnostic tests that may be quicker or more specific than conventional ones.
皮肤真菌感染会给健康和患病患者带来严重的发病风险。尽管有更新、更好的局部和全身治疗方法,但某些皮肤癣菌病的发病率仍在上升。在理想条件下,真菌残留物可存活数月至数年,从而使感染持续传播。由于感染源从其他伴随感染部位传播,在一个部位治疗的真菌病可能会复发。患者和医生未能早期识别真菌病因,可能导致感染更广泛、更严重或更难治疗。最后,患者的并发疾病可能会影响其对真菌感染的易感性和应对能力。出于这些原因,科学家们研究并开发了疗效更好、给药更方便的新型抗真菌药物。然而,这些药物仍然有副作用和药物相互作用,这可能会限制它们在某些患者中的使用。更好地对患者和医生进行教育,可能有助于更快地识别和治疗皮肤癣菌病。需要进行更多研究,以继续开发适用于更广泛患者群体的药物,以及比传统诊断测试更快或更具特异性的诊断测试。