Wojcik Barbara E, Spinks Martha K, Stein Catherine R
Center for AMEDD Strategic Studies (CASS), U.S. Army Medical Department Center and School, Fort Sam Houston, Texas 78234, USA.
Breast J. 2003 May-Jun;9(3):175-83. doi: 10.1046/j.1524-4741.2003.09308.x.
This study reviewed mammographic screening related to breast carcinoma diagnosis and treatment between 1987 and 1997 at Brooke Army Medical Center, San Antonio, TX. Epidemiologic data from the Department of Defense Automated Central Tumor Registry were merged with data from patients' medical records and responses of the patients or their families to a mailed survey. The cases of 907 women grouped by race-white, African American, and Hispanic-were analyzed. Breast carcinoma diagnosed by mammographic screening showed a reversed ratio of early to late stage of cancer occurring for all three groups. That ratio was 1.45 for African Americans, 2.67 for Hispanics, and 3.08 for whites. For those women diagnosed with screening mammography, no statistically significant difference in 5-year survival was found between the races: 86% for whites, 83% for Hispanics, and 80% for African Americans. Mammographic screening as a diagnostic tool appears to equalize survival among whites, Hispanics, and African Americans, in spite of differences in age, stage of diagnosis, and military rank used as a proxy for socioeconomic status. When not controlling for mammographic diagnosis, Kaplan-Meier analysis revealed significant differences in survival patterns between whites, Hispanics, and African Americans. Five-year survival rates were 71% for whites, 74% for Hispanics, and 53% for African Americans. Screening mammography reduced 5-year mortality by almost 59% in African Americans, 52% in whites, and 36% in Hispanics. Whites were diagnosed with breast carcinoma, on average, at 57 years of age-11 years later than African Americans (average age 46 years) and 7 years later than Hispanic women (average age 50 years). As a diagnostic tool, screening mammography was used to discover breast cancer in 36% of white women, 33% of Hispanics, and 22% of African Americans. Further research is recommended to examine the use of mammography among various racial/ethnic groups.
本研究回顾了1987年至1997年期间在德克萨斯州圣安东尼奥市布鲁克陆军医疗中心与乳腺癌诊断和治疗相关的乳房X线筛查情况。来自国防部自动中央肿瘤登记处的流行病学数据与患者病历数据以及患者或其家属对邮寄调查的回复进行了合并。对907名按种族(白人、非裔美国人和西班牙裔)分组的女性病例进行了分析。通过乳房X线筛查诊断出的乳腺癌在所有三个组中均显示出早期与晚期癌症发生比例的逆转。非裔美国人的这一比例为1.45,西班牙裔为2.67,白人为3.08。对于那些通过乳房X线筛查诊断出的女性,各种族之间的5年生存率没有统计学上的显著差异:白人86%,西班牙裔83%,非裔美国人80%。尽管在年龄、诊断阶段以及用作社会经济地位替代指标的军衔方面存在差异,但乳房X线筛查作为一种诊断工具似乎使白人、西班牙裔和非裔美国人的生存率趋于平等。在不控制乳房X线诊断的情况下,Kaplan-Meier分析显示白人、西班牙裔和非裔美国人在生存模式上存在显著差异。白人的5年生存率为71%,西班牙裔为74%,非裔美国人为53%。乳房X线筛查使非裔美国人的5年死亡率降低了近59%,白人降低了52%,西班牙裔降低了36%。白人被诊断出患有乳腺癌的平均年龄为57岁,比非裔美国人(平均年龄46岁)晚11年,比西班牙裔女性(平均年龄50岁)晚7年。作为一种诊断工具,乳房X线筛查在36%的白人女性、33%的西班牙裔女性和22%的非裔美国女性中用于发现乳腺癌。建议进一步研究以考察不同种族/族裔群体中乳房X线检查的使用情况。